Publications

Peer-reviewed papers (sorted by date in descending order)

* indicates co-first or co-senior authorship.
** indicates that mentee is first or co-first author

Weberpals J, Wang SV. External controls to study treatment effects in rare diseases: challenges and future directions. Clin Pharmacol Ther. 2024 (accepted)

Raman SR, Hammill BG, Shaw PA, Lee H, Toh S, Connolly JG, Dandreo KJ, Nalawade V, Tian F, Liu W, Li J, Hernández-Muñoz JJ, Glynn RJ, Desai RJ, Weberpals J. Analyzing Missingness Patterns in Real-world Data Using the SMDI Toolkit: Application to a Linked EHR-claims Pharmacoepidemiology Study. BMC Med Res Methodol. 2024 (accepted)

Ackerman B, Gan RW, Meyer CS, Wang JR, Zhang Y, Hayden J, Mahoney G, Lund JL, Weberpals J, Schneeweiss S, Roose J. Measurement error and bias in real-world oncology endpoints when constructing external control arms. Frontiers in Drug Safety and Regulation. 2024 Jul 19;4:1423493.

Weberpals J, Shaw, PA, Lin KJ, Wyss R, Plasek JM, Zhou L, Ngan K, DeRamus T, Raman SR, Hammill BG, Lee H, Toh S, Connolly JG, Dandreo KJ, Tian F, Liu W, Li J, Hernández-Muñoz JJ, Schneeweiss S, Desai, RJ. High-dimensional multiple imputation (HDMI) for partially observed confounders including natural language processing-derived auxiliary covariates. arXiv (2024).

Weberpals J, Raman SR, Shaw PA, Lee H, Russo M, Hammil BG, Toh D, Connolly JG, Dandreo KJ, Tian F, Liu W, Li Jie, Hernandez-Munos JJ, Glynn RJ, Desai RJ. A Principled Approach to Characterize and Analyze Partially Observed Confounder Data From Electronic Health Records. Clin Epidemiol. 2024. (accepted)

Weberpals J, Raman SR, Shaw PA, Lee H, Hammill BG, Toh S, Connolly JG, Dandreo KJ, Tian F, Liu W, Li J, Hernández-Muñoz JJ, Glynn RJ, Desai RJ. smdi: an R package to perform structural missing data investigations on partially observed confounders in real-world evidence studies. JAMIA Open. 2024 Jan 31;7(1):ooae008. doi: 10.1093/jamiaopen/ooae008. PMID: 38304248; PMCID: PMC10833461.

Desai RJ, Bradley M, Lee H, Eworuke E, Weberpals J, Wyss R, Schneeweiss S, Ball R. A simulation-based approach to assess the impact of unmeasured confounding when designing non-randomized database studies. Am J Epidemiol. 2023. (accepted)

Weberpals J, Wang SV. The FAIRification of research in real-world evidence: A practical introduction to reproducible analytic workflows using Git and R. Pharmacoepidemiol Drug Saf. Published online January 3, 2024. doi:10.1002/pds.5740

Sondhi A*, Weberpals J*, Yerram P, Jiang C, Taylor M, Samant M, Cherng S. A systematic approach towards missing lab data in electronic health records: A case study in non-small cell lung cancer and multiple myeloma. CPT Pharmacometrics Syst Pharmacol. 2023 Jun 15. doi: 10.1002/psp4.12998. Epub ahead of print. PMID: 37322818.

Jin Y, Weberpals J, Wang SV, Desai RJ, Merola D, Lin KJ. The Impact of Longitudinal Data-Completeness of Electronic Health Record Data on the Prediction Performance of Clinical Risk Scores. Clin Pharmacol Ther. 2023 Apr 7. doi: 10.1002/cpt.2901. Epub ahead of print. PMID: 37026443.

Weberpals J, Roumpanis S, Barer Y, Ehrlich S, Jessop N, Pedotti R, Vaknin-Dembinsky A, Brill L, Chodick G, Rouzic EM. Clinical outcomes of COVID-19 in patients with multiple sclerosis treated with ocrelizumab in the pre- and post-SARS-CoV-2 vaccination periods: Insights from Israel. Mult Scler Relat Disord. 2022 Dec;68:104153. doi: 10.1016/j.msard.2022.104153. Epub 2022 Aug 29. PMID: 36081277; PMCID: PMC9422340.

Graf RP, Fisher V, Weberpals J, Gjoerup O, Tierno MB, Huang RSP, Sayegh N, Lin DI, Raskina K, Schrock AB, Severson E, Haberberger JF, Ross JS, Creeden J, Levy MA, Alexander BM, MD, Oxnard GR, Agarwal N. Comparative Effectiveness of Immune Checkpoint Inhibitors vs. Chemotherapy by Tumor Mutational Burden in Metastatic Castration-Resistant Prostate Cancer. JAMA Netw Open. 2022;5(3):e225394. doi:10.1001/jamanetworkopen.2022.5394

Loureiro H**, Becker T, Bauer-Mehren A, Ahmidi N*, Weberpals J*. Artificial Intelligence for Prognostic Scores in Oncology: a Benchmarking Study. Front Artif Intell. 2021 Apr 16;4:625573. doi: 10.3389/frai.2021.625573. PMID: 33937744; PMCID: PMC8086599.

Weberpals J, Becker T, Davies J, Schmich F, Rüttinger D, Theis FJ, Bauer-Mehren A. Deep Learning-based Propensity Scores for Confounding Control in Comparative Effectiveness Research: A Large-scale, Real-world Data Study. Epidemiology. 2021 May 1;32(3):378-88. doi: 10.1097/EDE.0000000000001338. PMID: 33591049.

Jansen L, Holleczek B, Kraywinkel K, Weberpals J, Schröder CC, Eberle A, Emrich K, Kajüter H, Katalinic A, Kieschke J, Nennecke A, Sirri E, Heil J, Schneeweiss A, Brenner H. Divergent Patterns and Trends in Breast Cancer Incidence, Mortality and Survival Among Older Women in Germany and the United States. Cancers (Basel). 2020 Aug 26;12(9):2419. doi: 10.3390/cancers12092419. PMID: 32858964; PMCID: PMC7565138.

Brunssen A, Jansen L, Eisemann N, Waldmann A, Weberpals J, Kraywinkel K, Eberle A, Holleczek B, Zeissig SR, Brenner H, Katalinic A; GEKID Cancer Survival Working Group. Long-term relative survival from melanoma in Germany 1997-2013. Melanoma Res. 2020 Aug;30(4):386-95. doi: 10.1097/CMR.0000000000000482. PMID: 30020195.

Becker T, Weberpals J, Jegg AM, So WV, Fischer A, Weisser M, Schmich F, Rüttinger D, Bauer-Mehren A. An enhanced prognostic score for overall survival of patients with cancer derived from a large real-world cohort. Ann Oncol. 2020 Nov;31(11):1561-8. doi: 10.1016/j.annonc.2020.07.013. Epub 2020 Jul 31. PMID: 32739409.

Walter V, Boakye D, Weberpals J, Jansen L, Haefeli WE, Martens UM, Knebel P, Chang-Claude J, Hoffmeister M, Brenner H. Decreasing Use of Chemotherapy in Older Patients With Stage III Colon Cancer Irrespective of Comorbidities. J Natl Compr Canc Netw. 2019 Sep 1;17(9):1089-99. doi: 10.6004/jnccn.2019.7287. PMID: 31487678.

Perna L, Wahl HW, Weberpals J, Jansen L, Mons U, Schöttker B, Brenner H. Incident depression and mortality among people with different types of dementia: results from a longitudinal cohort study. Soc Psychiatry Psychiatr Epidemiol. 2019 Jul;54(7):793-801. doi: 10.1007/s00127-019-01683-0. Epub 2019 Mar 6. PMID: 30840093.

Muñoz MA, Jeon N, Staley B, Henriksen C, Xu D, Weberpals J, Winterstein AG. Predicting medication-associated altered mental status in hospitalized patients: Development and validation of a risk model. Am J Health Syst Pharm. 2019 Jun 18;76(13):953-63. doi: 10.1093/ajhp/zxz119. PMID: 31361885.

Pulte D, Weberpals J, Jansen L, Brenner H. Changes in population-level survival for advanced solid malignancies with new treatment options in the second decade of the 21st century. Cancer. 2019 Aug 1;125(15):2656-65. doi: 10.1002/cncr.32160. Epub 2019 May 16. PMID: 31095726.

Brunssen A, Jansen L, Eisemann N, Waldmann A, Weberpals J, Kraywinkel K, Eberle A, Holleczek B, Zeissig SR, Brenner H, Katalinic A; GEKID Cancer Survival Working Group. A population-based registry study on relative survival from melanoma in Germany stratified by tumor thickness for each histologic subtype. J Am Acad Dermatol. 2019 Apr;80(4):938-46. doi: 10.1016/j.jaad.2018.09.018. Epub 2018 Sep 20. PMID: 30244061.

Weberpals J, Jansen L, Silversmit G, Verbeeck J, van der Geest L, Vissers PA, Zadnik V, Brenner H. Comparative performance of a modified landmark approach when no time of treatment data are available within oncological databases: exemplary cohort study among resected pancreatic cancer patients. Clin Epidemiol. 2018 Aug 30;10:1109-25. doi: 10.2147/CLEP.S160973. PMID: 30214315; PMCID: PMC6121745.

Weberpals J, Jansen L, Müller OJ, Brenner H. Long-term heart-specific mortality among 347 476 breast cancer patients treated with radiotherapy or chemotherapy: a registry-based cohort study. Eur Heart J. 2018 Nov 14;39(43):3896-903. doi: 10.1093/eurheartj/ehy167. PMID: 29635274.

Pulte D, Weberpals J, Schröder CC, Emrich K, Holleczek B, Katalinic A, Luttmann S, Sirri E, Jansen L, Brenner H; GEKID Cancer Survival Working Group. Survival of patients with hepatobiliary tract and duodenal cancer sites in Germany and the United States in the early 21st century. Int J Cancer. 2018 Jul 15;143(2):324-32. doi: 10.1002/ijc.31322. Epub 2018 Mar 5. PMID: 29479701.

Carr PR*, Alwers E*, Bienert S, Weberpals J, Kloor M, Brenner H, Hoffmeister M. Lifestyle factors and risk of sporadic colorectal cancer by microsatellite instability status: a systematic review and meta-analyses. Ann Oncol. 2018 Apr 1;29(4):825-34. doi: 10.1093/annonc/mdy059. PMID: 29438474.

Weberpals J, Jansen L, van Herk-Sukel MPP, Kuiper JG, Aarts MJ, Vissers PAJ, Brenner H. Immortal time bias in pharmacoepidemiological studies on cancer patient survival: empirical illustration for beta-blocker use in four cancers with different prognosis. Eur J Epidemiol. 2017 Nov;32(11):1019-31. doi: 10.1007/s10654-017-0304-5. Epub 2017 Sep 1. PMID: 28864947.

Pulte D*, Weberpals J*, Jansen L, Luttmann S, Holleczek B, Nennecke A, Ressing M, Katalinic A, Brenner H; GEKID Cancer Survival Working Group. Survival for patients with rare haematologic malignancies: Changes in the early 21st century. Eur J Cancer. 2017 Oct;84:81-7. doi: 10.1016/j.ejca.2017.07.014. Epub 2017 Aug 8. PMID: 28800491.

Weberpals J, Jansen L, Haefeli WE, Hoffmeister M, Wolkewitz M, Herk-Sukel MPPV, Vissers PAJ, Brenner H. Pre- and post-diagnostic β-blocker use and lung cancer survival: A population-based cohort study. Sci Rep. 2017 Jun 6;7(1):2911. doi: 10.1038/s41598-017-02913-8. PMID: 28588274; PMCID: PMC5460218.

Weberpals J*, Pulte D*, Jansen L, Luttmann S, Holleczek B, Nennecke A, Ressing M, Katalinic A, Merz M, Brenner H; GEKID Cancer Survival Working Group. Survival of patients with lymphoplasmacytic lymphoma and solitary plasmacytoma in Germany and the United States of America in the early 21st century. Haematologica. 2017 Jun;102(6):e229-32. doi: 10.3324/haematol.2016.157768. Epub 2017 Mar 9. PMID: 28280077; PMCID: PMC5451350.

Jansen L, Weberpals J, Kuiper JG, Vissers PAJ, Wolkewitz M, Hoffmeister M, Brenner H. Pre- and post-diagnostic beta-blocker use and prognosis after colorectal cancer: Results from a population-based study. Int J Cancer. 2017 Jul 1;141(1):62-71. doi: 10.1002/ijc.30717. PMID: 28370155.

Muhlack DC, Hoppe LK, Weberpals J, Brenner H, Schöttker B. The Association of Potentially Inappropriate Medication at Older Age With Cardiovascular Events and Overall Mortality: A Systematic Review and Meta-Analysis of Cohort Studies. J Am Med Dir Assoc. 2017 Mar 1;18(3):211-20. doi: 10.1016/j.jamda.2016.11.025. Epub 2017 Jan 26. PMID: 28131719.

Weberpals J, Jansen L, Carr PR, Hoffmeister M, Brenner H. Beta blockers and cancer prognosis - The role of immortal time bias: A systematic review and meta-analysis. Cancer Treat Rev. 2016 Jun;47:1-11. doi: 10.1016/j.ctrv.2016.04.004. Epub 2016 Apr 26. PMID: 27179912.

Non-Peer Reviewed Scientific or Medical Publications in Print or Other Media

Reviews, chapters, monographs and editorials

Brenner H, Weberpals J, Jansen L. Epidemiologische Forschung mit Krebsregisterdaten, Überlebenszeitanalysen, Vergleich nationaler und internationaler Ergebnisse. [Epidemiological research-cancer registry data. Survival time analysis-comparison of national and international results.] ONKOLOGE. 2017 Apr 1;23(4):272-9. (Article in German)

Weberpals J, Brenner H. Epidemiologie und Risikofaktoren kardiovaskulärer und onkologischer Erkrankungen [Epidemiology and risk factors of cardiovascular and oncological diseases]. In: Müller OJ, Lehmann L, Bokemeyer C. Kardio-Onkologie. Berlin. DeGruyter, 2022 (Book chapter in German)

Books, monographs, articles and presentations in other media

Weberpals J. Krebsprognose und Betablocker - Eine Frage des Studiendesigns [Cancer prognosis and beta-blockers - study design matters.] Pharm Ztg 2016;24. (Article in German) Available From: https://www.pharmazeutische-zeitung.de/ausgabe-242016/eine-frage-des-studiendesigns/

Letters to the Editor

Weberpals J, Carr PR, Hoffmeister M, Jansen L. Comment on: ‘β Blocker use and mortality in cancer patients: systematic review and meta-analysis of observational studies’ (Zhong et al., 2015; published Epub ahead of print 3 September 2015). Eur J Cancer Prev. 2018 Jan;27(1):103-4. doi: 10.1097/CEJ.0000000000000243. PMID: 29369941.

Thesis

Weberpals J. Associations between β-blocker exposure and cancer prognosis: the role of immortal time bias and analytical approaches in pharmacoepidemiological studies on cancer patient survival. [Doctor Scientiarum Humanarum Dissertation], Medical Faculty of Heidelberg, Rupert Carola University Heidelberg, Germany; 2018